In an address published on Facebook, Morawiecki said his country was facing its most difficult moment in the fight against the pandemic.
"That's why I would like to address you with an appeal: let us stay at home this Easter, in the company of our immediate family, among those with whom we live every day. I know how difficult it is. I know that we are all very tired of this situation. But let's do this for our loved ones, for our families and for ourselves."
Easter is usually when Poles spend time with their extended families and travel extensively to visit their relatives. Officials have this year urged Poles to scrap any travel plans.
Morawiecki wished his countrymen a safe Easter, adding: "Even after the darkest night, day finally arrives. And normality will also return after the pandemic."
Poland on Friday reported 30,546 new coronavirus infections and 497 more deaths, bringing its total number of cases during the pandemic to 2,387,511 and fatalities to 54,165.
On Thursday, Poland confirmed a record 35,251 new coronavirus infections nationwide.
On November 25, the country reported its highest daily toll of 674 deaths related to the coronavirus.