UNICEF spokesman James Elder told reporters that only two in five potable-water plants remain working after months of war and blockade.
“Children will begin to die of thirst,” he said.
The warning follows UNICEF data showing more than 5,000 Gazan children were treated for malnutrition in May, up 50 percent from April and 150 percent since February, when a brief ceasefire allowed greater aid deliveries.
Aid groups say fuel shortages, damaged pumps and restrictions on relief convoys have crippled desalination and distribution systems in the enclave of 2.3 million people.
Israel says it lets sufficient supplies enter but must prevent aid from reaching Hamas.
UN agencies have repeatedly cautioned that famine is looming unless water, food and medical shipments rise sharply and distribution becomes safer.
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Source: The Guardian, UNICEF