Macron is due to visit Poland on Monday for a Polish-French summit, the first since the two countries signed a treaty on enhanced cooperation and friendship in May last year.
Tusk said discussions would focus on strengthening European security, including cooperation involving France’s nuclear capabilities.
"How to build Europe’s strength, how to build the sovereignty of Poland, France and Europe, and how to cooperate on security, including using France's nuclear potential—these will be key issues," Tusk told a news conference on Friday.
He said the talks in the northern Polish city of Gdańsk come at a time of shifting US strategy toward Europe, the Middle East conflict and Russia's ongoing war in Ukraine.
Tusk stressed the importance of maintaining strong transatlantic ties and expressed hope that the United States and Europe would remain united in supporting Ukraine, Polish state news agency PAP reported.
"Our American friends must understand that the European Union is the best thing that has happened to Europe," he said, warning against efforts to destabilise the bloc.
According to the French presidency, Macron will be accompanied by several ministers, including those responsible for defence, foreign affairs, culture and energy.
Tusk and Macron are also expected to take part in symbolic events in Gdańsk, including laying flowers at a monument to the victims of the 1970 shipyard protests and visiting the European Solidarity Centre.
The summit coincides with the first observance of Polish-French Friendship Day, established under the bilateral treaty signed last year in Nancy, northeastern France.
The agreement includes mutual security guarantees and expanded cooperation in defence, the economy, agriculture, science and culture.
Officials said the talks will also cover bilateral relations, European security challenges and broader transatlantic cooperation.
Tusk said last month that Poland was in talks with France and a group of European allies on an advanced nuclear deterrence programme.
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Source: IAR, PAP