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Polish team tests sleep-based device to aid Alzheimer’s patients

22.10.2025 12:45
A research group in Łódź has built a noninvasive device that stimulates the vagus nerve during sleep and showed early signs of improving memory and daily functioning in people with Alzheimer’s disease.
In preliminary studies lasting three to six months with more than 50 early-stage patients, researchers reported statistically significant cognitive gains and better orientation, concentration and daily activity.
In preliminary studies lasting three to six months with more than 50 early-stage patients, researchers reported statistically significant cognitive gains and better orientation, concentration and daily activity. Photo: Shutterstock

The textile headband, called Vguard, delivers imperceptible electrical impulses in sync with a patient’s sleep rhythm—mainly during REM—to support memory consolidation. The system is managed by a mobile app and is protected by five global patents, the team said.

Led by neurologist Prof. Adam Broncel, the group has explored neuromodulation for a decade as an alternative to drugs that largely offer only symptomatic relief.

In preliminary studies lasting three to six months with more than 50 early-stage patients, researchers reported statistically significant cognitive gains and better orientation, concentration and daily activity. The device was well tolerated.

A smaller test in Tel Aviv with advanced-stage patients showed similar but weaker effects, which the team said supports earlier use of the therapy.

Vguard has received the CE medical mark for use in Europe but is not commercially available. Results were presented at the 35th European Alzheimer’s Society conference in Bologna, and broader multi-center trials in Poland and across Europe are being prepared.

(jh)

Source: PAP