The game at the Silesian Stadium in the southern city of Chorzów kicks off at 8:45 p.m. local time.
Poland are ranked 31st worldwide by football's governing body FIFA, while Moldova are No. 154 in the FIFA table.
On June 10, the Polish team will face Finland in a World Cup qualifier in Helsinki.
Manager Michał Probierz last week released a list of 26 players called up for the two games.
(gs)
Source: IAR, PAP