This time the charity drive, which is now in its 31st year, will be raising money to support early diagnosis of the bacterial infection that causes sepsis.
Polish celebrities including tennis champion Iga Świątek and football star Robert Lewandowski have pitched in by putting up personal items for a charity auction.
The traditional collection will see volunteers, equipped with the event's signature boxes and heart-shaped stickers, taking to the streets of towns and cities across Poland and beyond.
In an interview with Michał Owczarek, Prof. Bohdan Maruszewski, a pediatric cardiac surgeon and co-founder of the Great Orchestra of Christmas Charity, gives the highlights of this year’s Grand Finale set for Sunday.
Click on the audio player above to listen.