Of the new cases confirmed on Saturday, 4,506 were in the southern coal mining region of Silesia.
Meanwhile, 4,115 new infections were reported in the central region of Mazowieckie, which includes the national capital Warsaw.
The western province of Wielkopolskie, which is home to the major city of Poznań, had the third-highest number of new infections confirmed by officials on Saturday, at 2,779.
The latest deaths in Poland’s coronavirus outbreak are 426 people with pre-existing medical conditions and 145 who died directly because of COVID-19, the Polish health ministry said.
On Thursday, Poland confirmed 621 deaths and a record 35,251 new coronavirus infections nationwide.
Poland’s second-highest number of daily cases was when 35,143 new coronavirus infections were confirmed nationwide on March 26.
On November 25, the country reported its highest daily toll of 674 deaths related to the coronavirus.
Poland's first case of coronavirus infection was reported on March 4, 2020.