Officials and diplomats from many countries are also scheduled to take part in the event, which aims to pay tribute to the victims of the Holocaust.
Marchers will walk the 3-kilometre route from the Auschwitz death camp's infamous “Arbeit macht frei” (Work Sets You Free) gate to the crematoria of the nearby Birkenau site.
They will be led by a group of 55 Holocaust survivors from around the world.
Launched in 1988, the March of the Living is as an international educational project that honours Holocaust victims.
The Auschwitz-Birkenau camp operated in German-occupied southern Poland between May 1940 and January 1945. It was the largest of the German Nazi concentration and death camps during World War II.
More than 1.1 million people, mostly European Jews, as well as Poles, Roma, Soviet POWs and people of many other nationalities, perished there before the camp was liberated on January 27, 1945.
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Source: IAR, PAP