The lineup announced by Paulo Sousa this week includes star striker Robert Lewandowski and other well-known faces such as Napoli midfielder Piotr Zieliński and Hertha Berlin striker Krzysztof Piątek.
Young guns include AS Roma midfielder Nicola Zalewski and Pogoń Szczecin player Kacper Kozłowski, a 17-year-old who has been hailed as "the talent of the century" and drawn interest from clubs such as Manchester United.
Another fresh face is New England Revolution forward Adam Buksa.
Poland play a World Cup qualifier against Albania on home turf in Warsaw on September 2.
Three days later the Poles will take on San Marino in their next qualifying fixture in Serravalle.
On September 8, Poland will play England at home in Warsaw.
The Polish team opened its 2022 World Cup qualifying campaign with a 3-3 away draw with Hungary in Budapest on March 25.
The Poles, captained by Lewandowski, FIFA's world player of the year for 2020, then beat Andorra 3-0 in their second World Cup qualifier at home on March 28.
Poland in late March lost 1-2 to England in their third 2022 World Cup qualifier in London.
The qualification stage for the 2022 World Cup will run from until November 2021, while the tournament will be held in Qatar from November 21 to December 18, 2022.
Here is the full Poland squad for the September matches against Albania, San Marino and England:
Goalkeepers:
Bartłomiej Drągowski (Fiorentina)
Łukasz Skorupski (Bologna)
Wojciech Szczęsny (Juventus)
Defenders:
Jan Bednarek (Southampton)
Bartosz Bereszyński (Sampdoria)
Paweł Dawidowicz (Hellas Verona)
Kamil Glik (Benevento Calcio)
Michał Helik (Barnsley)
Tomasz Kędziora (Dynamo Kyiv)
Tymoteusz Puchacz (Union Berlin)
Maciej Rybus (Lokomotiv Moscow)
Midfielders:
Przemysław Frankowski (RC Lens)
Kamil Jóźwiak (Derby County)
Mateusz Klich (Leeds United)
Kacper Kozłowski (Pogoń Szczecin)
Grzegorz Krychowiak (Krasnodar)
Karol Linetty (Torino)
Jakub Moder (Brighton & Hove Albion)
Sebastian Szymański (Dynamo Moscow)
Nicola Zalewski (AS Roma)
Piotr Zieliński (Napoli)
Forwards:
Adam Buksa (New England Revolution)
Dawid Kownacki (Fortuna Düsseldorf)
Robert Lewandowski (Bayern Munich)
Krzysztof Piątek (Hertha Berlin)
Karol Świderski (PAOK Salonika)
(gs)
Source: PAP, pzpn.pl